Are Probiotics Effective for Respiratory Allergies and Gut Microbiota?

World No Tobacco Day 2020
World No Tobacco Day 2020
This episode is also available as a blog post: https://mdforlives.blog/2020/06/05/world-no-tobacco-day-2020/ --- ...
00:09:34
July 06, 2022
Minimally Invasive Glaucoma Surgery
Minimally Invasive Glaucoma Surgery
This episode is also available as a blog post: https://mdforlives.blog/2022/05/06/minimally-invasive-glaucoma-surg...
00:06:15
May 06, 2022
Speed the Cure: Don’t Let Your Patients be blindsided by Glaucoma
Speed the Cure: Don’t Let Your Patien...
This episode is also available as a blog post: https://mdforlives.blog/2022/05/06/speed-the-cure-dont-let-your-pat...
00:07:48
May 06, 2022
Information that can keep you updated with medical and health
Information that can keep you updated w...
This episode is also available as a blog post: https://mdforlives.blog/2022/05/05/information-that-can-keep-you-up...
00:07:08
May 05, 2022
Can nutrigenomics help with the advancement of personalized nutrition?
Can nutrigenomics help with the advance...
This episode is also available as a blog post: https://mdforlives.blog/2022/05/04/can-nutrigenomics-help-with-the-...
00:05:13
May 04, 2022
Human primordial germ-cell-like cell (PGCLC) preservation for reproductive health research
Human primordial germ-cell-like cell (P...
This episode is also available as a blog post: https://mdforlives.blog/2022/04/29/human-primordial-germ-cell-like-...
00:04:28
April 29, 2022
FDA approves first disease-modifying therapy for a rare blood disorder
FDA approves first disease-modifying th...
This episode is also available as a blog post: https://mdforlives.blog/2022/04/29/fda-approves-first-disease-modif...
00:04:32
April 29, 2022
Cystic fibrosis developments and pipeline drugs
Cystic fibrosis developments and pipeli...
This episode is also available as a blog post: https://mdforlives.blog/2022/04/27/cystic-fibrosis-developments-and...
00:06:02
April 27, 2022
Addition of a spider silk protein to p53 shuts down cancer cells
Addition of a spider silk protein to p5...
This episode is also available as a blog post: https://mdforlives.blog/2022/04/26/addition-of-a-spider-silk-protei...
00:07:55
April 26, 2022
Gut microbes’ evolutionary responses to diet could affect human health
Gut microbes’ evolutionary responses ...
This episode is also available as a blog post: https://mdforlives.blog/2022/04/22/gut-microbes-evolutionary-respon...
00:05:27
April 22, 2022
Novel AI Olfactory Device for Detecting Parkinson’s Disease
Novel AI Olfactory Device for Detecting...
This episode is also available as a blog post: https://mdforlives.blog/2022/04/22/novel-ai-olfactory-device-for-de...
00:05:57
April 22, 2022
Drunken monkey hypothesis: Sheds light on human’s inherited love for alcohol
Drunken monkey hypothesis: Sheds light ...
This episode is also available as a blog post: https://mdforlives.blog/2022/04/21/drunken-monkey-hypothesis-sheds-...
00:04:20
April 21, 2022
Camptothecin: An anti-cancer drug that induces weight loss
Camptothecin: An anti-cancer drug that ...
This episode is also available as a blog post: https://mdforlives.blog/2022/04/21/camptothecin-an-anti-cancer-drug...
00:06:59
April 21, 2022
Even a virtual classroom can improve your child’s reading skill
Even a virtual classroom can improve yo...
This episode is also available as a blog post: https://mdforlives.blog/2022/04/19/even-a-virtual-classroom-can-imp...
00:07:41
April 19, 2022
Do you know that Amygdala Overgrowth Occurs in the First Year of Life?
Do you know that Amygdala Overgrowth Oc...
This episode is also available as a blog post: https://mdforlives.blog/2022/04/18/do-you-know-that-amygdala-overgr...
00:06:47
April 18, 2022
Gene therapy: A boon in medical science
Gene therapy: A boon in medical science
This episode is also available as a blog post: https://mdforlives.blog/2022/04/13/gene-therapy-a-boon-in-medical-s...
00:08:28
April 13, 2022
Are Our Perceptions of Reality True?
Are Our Perceptions of Reality True?
This episode is also available as a blog post: https://mdforlives.blog/2022/04/12/are-our-perceptions-of-reality-t...
00:06:21
April 12, 2022
Benefits of Mindfulness Training: Antidote to Physician Burnout
Benefits of Mindfulness Training: Antid...
This episode is also available as a blog post: https://mdforlives.blog/2022/04/06/benefits-of-mindfulness-training...
00:06:54
April 06, 2022
Is oral immunotherapy promising to treat peanut allergy in children?
Is oral immunotherapy promising to trea...
This episode is also available as a blog post: https://mdforlives.blog/2022/04/04/is-oral-immunotherapy-promising-...
00:06:49
April 04, 2022
Researchers utilized a smartphone app to develop a novel blood-clotting test that is both affordable and accessible to millions of people across the world
Researchers utilized a smartphone app t...
This episode is also available as a blog post: https://mdforlives.blog/2022/04/01/researchers-utilized-a-smartphon...
00:06:58
April 01, 2022
Technique for changing the blood type of donor lungs could save lives
Technique for changing the blood type o...
This episode is also available as a blog post: https://mdforlives.blog/2022/03/30/technique-for-changing-the-blood...
00:06:08
March 30, 2022
Complex kidney tissue generated entirely from mouse embryonic stem cells for improved kidney research and, eventually, artificial kidney transplantation
Complex kidney tissue generated entirel...
This episode is also available as a blog post: https://mdforlives.blog/2022/03/29/complex-kidney-tissue-generated-...
00:05:37
March 29, 2022
Are you aware of the recent happenings in medical science?
Are you aware of the recent happenings ...
This episode is also available as a blog post: https://mdforlives.blog/2022/03/22/are-you-aware-of-the-recent-happ...
00:09:35
March 22, 2022
Rare discovery of an amino acid sensor present in all life forms
Rare discovery of an amino acid sensor ...
This episode is also available as a blog post: https://mdforlives.blog/2022/03/21/rare-discovery-of-an-amino-acid-...
00:06:49
March 21, 2022
Future healthcare Tech Trends in 2022
Future healthcare Tech Trends in 2022
This episode is also available as a blog post: https://mdforlives.blog/2022/03/18/future-healthcare-tech-trends-in...
00:09:20
March 18, 2022
Proton MR Spectroscopy, a new MRI method, may aid in the diagnosis and treatment of multiple sclerosis
Proton MR Spectroscopy, a new MRI metho...
This episode is also available as a blog post: https://mdforlives.blog/2022/03/16/proton-mr-spectroscopy-a-new-mri...
00:05:14
March 16, 2022
Ion channel may link hyperglycemia to clotting risk in diabetes
Ion channel may link hyperglycemia to c...
This episode is also available as a blog post: https://mdforlives.blog/2022/03/10/ion-channel-may-link-hyperglycem...
00:06:35
March 10, 2022
The Battle: Omicron Vs Pfizer Vaccine
The Battle: Omicron Vs Pfizer Vaccine
This episode is also available as a blog post: https://mdforlives.blog/2022/03/09/the-battle-omicron-vs-pfizer-vac...
00:06:34
March 09, 2022
Evidence-based medicine – PICO and How to develop answerable clinical questions?
Evidence-based medicine – PICO and Ho...
This episode is also available as a blog post: https://mdforlives.blog/2022/03/04/evidence-based-medicine-pico-and...
00:06:01
March 04, 2022
Breakthroughs in Research to Bloom the Future of Medical Science
Breakthroughs in Research to Bloom the ...
This episode is also available as a blog post: https://mdforlives.blog/2022/03/01/breakthroughs-in-research-to-blo...
00:08:53
March 01, 2022
Researchers have gained a better understanding of the brain region that controls satiation, which might lead to more effective therapies for eating disorders and weight loss
Researchers have gained a better unders...
This episode is also available as a blog post: https://mdforlives.blog/2022/02/28/eating-disorders-and-weight-loss...
00:05:48
February 28, 2022
Research on COVID-19 can steer the world onto a safer, more sustainable path
Research on COVID-19 can steer the worl...
This episode is also available as a blog post: https://mdforlives.blog/2022/02/24/research-on-covid-19-can-steer-t...
00:06:06
February 24, 2022
Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
This episode is also available as a blog post: https://mdforlives.blog/2022/02/24/chronic-lymphocytic-leukemia-the...
00:06:35
February 24, 2022
Restoring heart rate variability by the ‘Bionic’ pacemaker
Restoring heart rate variability by the...
This episode is also available as a blog post: https://mdforlives.blog/2022/02/18/restoring-heart-rate-variability...
00:05:12
February 18, 2022
Clostridioides difficile infection and the microbiome
Clostridioides difficile infection and ...
This episode is also available as a blog post: https://mdforlives.blog/2022/02/18/clostridioides-difficile-infecti...
00:06:11
February 18, 2022
NTRK fusion tumors in adult and pediatric patients
NTRK fusion tumors in adult and pediatr...
This episode is also available as a blog post: https://mdforlives.blog/2022/02/16/ntrk-fusion-tumors-in-adult-and-...
00:06:13
February 18, 2022
Eliminating or decreasing the number of HIV-infected cells in people who might otherwise require medication
Eliminating or decreasing the number of...
This episode is also available as a blog post: https://mdforlives.blog/2022/02/10/eliminating-or-decreasing-the-nu...
00:04:34
February 10, 2022
Can some appendicitis patients be treated without surgery
Can some appendicitis patients be treat...
This episode is also available as a blog post: https://mdforlives.blog/2022/02/08/appendicitis-patients-be-treated...
00:05:13
February 08, 2022
Be careful, moms-to-be: Infant mortality risk is linked to mother’s vaginal microbiome
Be careful, moms-to-be: Infant mortalit...
This episode is also available as a blog post: https://mdforlives.blog/2022/02/08/moms-to-be-infant-mortality-risk...
00:09:22
February 08, 2022
Alcohol: A direct carcinogen impairing DNA repair
Alcohol: A direct carcinogen impairing ...
This episode is also available as a blog post: https://mdforlives.blog/2022/01/28/alcohol-a-direct-carcinogen-impa...
00:09:21
January 28, 2022
Let’s focus on how to keep and improve your thyroid health this year!
Let’s focus on how to keep and improv...
This episode is also available as a blog post: https://mdforlives.blog/2022/01/28/lets-focus-on-how-to-keep-and-im...
00:15:27
January 28, 2022
 adverse side reactions of 4 new FDA-approved drugs
adverse side reactions of 4 new FDA-ap...
This episode is also available as a blog post: https://mdforlives.blog/2022/01/24/do-you-know-the-adverse-side-rea...
00:10:16
January 24, 2022
To know what you know and what you do not know: Case studies of illnesses with mystifying presentations
To know what you know and what you do n...
This episode is also available as a blog post: https://mdforlives.blog/2022/01/24/illnesses-with-mystifying-presen...
00:10:12
January 24, 2022
Are you aware that the nervous system is the key to maximum health?
Are you aware that the nervous system i...
This episode is also available as a blog post: https://mdforlives.blog/2022/01/24/are-you-aware-that-the-nervous-s...
00:08:49
January 24, 2022
New analysis suggests that an existing drug can be useful for migraine with aura
New analysis suggests that an existing ...
This episode is also available as a blog post: https://mdforlives.blog/2022/01/24/erenumab-for-migraine-with-aura/...
00:05:25
January 24, 2022
Langerhans cell histiocytosis: Behind the Mystery
Langerhans cell histiocytosis: Behind t...
This episode is also available as a blog post: https://mdforlives.blog/2022/01/20/langerhans-cell-histiocytosis-be...
00:06:55
January 20, 2022
Rare disease advances: FDA approves three new treatments
Rare disease advances: FDA approves thr...
This episode is also available as a blog post: https://mdforlives.blog/2022/01/18/rare-disease-fda-approves-new-tr...
00:07:42
January 18, 2022
Eyes Are Very Precious – Save Them If You Have Glaucoma!!
Eyes Are Very Precious – Save Them If...
This episode is also available as a blog post: https://mdforlives.blog/2022/01/13/eyes-are-precious-glaucoma/ ---...
00:09:43
January 13, 2022
Real-world evidence vs clinical trials
Real-world evidence vs clinical trials
This episode is also available as a blog post: https://mdforlives.blog/2022/01/12/real-world-evidence-vs-clinical-...
00:05:34
January 12, 2022
Longer life vs a better death
Longer life vs a better death
This episode is also available as a blog post: https://mdforlives.blog/2022/01/12/longer-life-vs-better-death/ --...
00:07:42
January 12, 2022
Intravenous or Nebulized Magnesium sulfate: Which One Should you Choose?
Intravenous or Nebulized Magnesium sulf...
This episode is also available as a blog post: https://mdforlives.blog/2022/01/11/intravenous-or-nebulized-magnesi...
00:08:56
January 11, 2022
Clarifying the use of thiazide diuretics in Stage 4 chronic kidney disease
Clarifying the use of thiazide diuretic...
This episode is also available as a blog post: https://mdforlives.blog/2022/01/10/stage-4-chronic-kidney-disease/ ...
00:06:11
January 10, 2022
Advancements in clinical trials can pave the way to innovative treatment
Advancements in clinical trials can pav...
This episode is also available as a blog post: https://mdforlives.blog/2022/01/07/clinical-trials-can-pave-the-way...
00:06:14
January 07, 2022
Cervical Cancer: It’s Not Only Preventable But Treatable
Cervical Cancer: It’s Not Only Preven...
This episode is also available as a blog post: https://mdforlives.blog/2022/01/05/cervical-cancer-its-not-only-pre...
00:09:35
January 05, 2022
Wondering about new treatment options for complicated disorders affecting the quality of life?
Wondering about new treatment options f...
This episode is also available as a blog post: https://mdforlives.blog/2021/12/31/new-treatment-for-complicated-di...
00:07:27
December 31, 2021
Hurler syndrome gene therapy shows early success in a small study
Hurler syndrome gene therapy shows earl...
This episode is also available as a blog post: https://mdforlives.blog/2021/12/30/hurler-syndrome-gene-therapy/ -...
00:07:11
December 30, 2021
Management of rare mutations in non-small cell lung cancer (NSCLC) – PART 3: HER2
Management of rare mutations in non-sma...
This episode is also available as a blog post: https://mdforlives.blog/2021/12/21/part3-management-of-rare-mutatio...
00:09:47
December 21, 2021
Management of rare mutations in non-small cell lung cancer (NSCLC) – PART 2: RET, NTRK1
Management of rare mutations in non-sma...
This episode is also available as a blog post: https://mdforlives.blog/2021/12/20/part2-management-of-rare-mutatio...
00:08:16
December 20, 2021
Cancer may have started the fight but new research on oncology will open many doors and end the war
Cancer may have started the fight but n...
This episode is also available as a blog post: https://mdforlives.blog/2021/12/17/new-research-on-oncology-will-op...
00:10:59
December 17, 2021
Infectious Disorders: In Light of Current Research
Infectious Disorders: In Light of Curre...
This episode is also available as a blog post: https://mdforlives.blog/2021/12/14/infectious-disorders-in-light-of...
00:12:02
December 17, 2021
Recent Medical Breakthroughs to See a Change in the World
Recent Medical Breakthroughs to See a C...
This episode is also available as a blog post: https://mdforlives.blog/2021/12/10/medical-breakthroughs-to-see-a-c...
00:11:27
December 13, 2021
Genome sequencing project finds answers for 25% of rare disease patients in a study
Genome sequencing project finds answers...
This episode is also available as a blog post: https://mdforlives.blog/2021/12/13/genome-sequencing-project-in-rar...
00:05:49
December 13, 2021
How Oncology Research in 2021 Shed Light on Therapy Area? 
How Oncology Research in 2021 Shed Ligh...
This episode is also available as a blog post: https://mdforlives.blog/2021/12/08/how-oncology-research-in-2021-sh...
00:11:16
December 13, 2021
Management of rare mutations in non-small cell lung cancer (NSCLC) – PART 1: MET, ROS1, and ALK
Management of rare mutations in non-sma...
This episode is also available as a blog post: https://mdforlives.blog/2021/12/06/part1-management-of-rare-mutatio...
00:09:00
December 06, 2021
Investigational drug shows early success in the treatment of nonalcoholic steatohepatitis 
Investigational drug shows early succes...
This episode is also available as a blog post: https://mdforlives.blog/2021/12/03/investigational-drug-in-treatmen...
00:05:57
December 06, 2021
Using viruses to outsmart antibiotic-resistant bacteria
Using viruses to outsmart antibiotic-re...
This episode is also available as a blog post: https://mdforlives.blog/2021/11/26/using-viruses-to-outsmart-antibi...
00:08:24
November 26, 2021
Daratumumab for AL amyloidosis: promising results in a tough disease
Daratumumab for AL amyloidosis: promisi...
This episode is also available as a blog post: https://mdforlives.blog/2021/11/25/daratumumab-for-al-amyloidosis-d...
00:08:32
November 25, 2021
<strong data-recalc-dims=FDA approves first treatment for congenital athymia">
FDA approves first treatment fo...
This episode is also available as a blog post: https://mdforlives.blog/2021/11/22/fda-approves-first-treatment-for...
00:05:22
November 22, 2021
Management of long-term health in women with PCOS
Management of long-term health in women...
This episode is also available as a blog post: https://mdforlives.blog/2021/11/19/management-of-long-term-health-i...
00:07:32
November 19, 2021
How to know the status of acute lymphoblastic leukemia from epigenetic DNA modification?
How to know the status of acute lymphob...
This episode is also available as a blog post: https://mdforlives.blog/2021/11/16/know-the-status-of-acute-lymphob...
00:08:33
November 17, 2021
Using viruses to outsmart antibiotic-resistant bacteria
Using viruses to outsmart antibiotic-re...
This episode is also available as a blog post: https://mdforlives.blog/2021/10/18/using-viruses-to-outsmart-antibi...
00:08:10
November 02, 2021
Abnormal Tau Protein- A hallmark indicator of Alzheimer’s disease
Abnormal Tau Protein- A hallmark indica...
This episode is also available as a blog post: https://mdforlives.blog/2021/10/11/abnormal-tau-protein-hallmark-in...
00:07:59
November 02, 2021
Salt substitution for hypertension helps lower cardiovascular risks
Salt substitution for hypertension help...
This episode is also available as a blog post: https://mdforlives.blog/2021/10/13/salt-substitution-hypertension-h...
00:07:16
November 02, 2021
New insights into the causes of endometriosis could lead to treatments
New insights into the causes of endomet...
This episode is also available as a blog post: https://mdforlives.blog/2021/10/20/new-insights-into-causes-of-endo...
00:06:21
November 02, 2021
How safe is breast reconstruction during the COVID-19 pandemic? 
How safe is breast reconstruction durin...
This episode is also available as a blog post: https://mdforlives.blog/2021/10/28/how-safe-is-breast-reconstructio...
00:07:18
November 02, 2021
A healthy gut microbiome may help prevent colorectal cancer
A healthy gut microbiome may help preve...
This episode is also available as a blog post: https://mdforlives.blog/2021/11/02/healthy-gut-microbiome-prevent-c...
00:06:15
November 02, 2021
Enhancing Food Safety Practices amid The Worldwide Pandemic
Enhancing Food Safety Practices amid Th...
This episode is also available as a blog post: https://mdforlives.blog/2020/06/09/enhancing-food-safety-practices-...
00:05:14
November 02, 2021
Beware cancer cells – the Oncolytic virus is coming for you!
Beware cancer cells – the Oncolytic v...
This episode is also available as a blog post: https://mdforlives.blog/2021/07/19/oncolytic-virus-is-coming-for-ca...
00:07:20
September 06, 2021
What foods really fight cancer?
What foods really fight cancer?
This episode is also available as a blog post: https://mdforlives.blog/2021/09/06/what-foods-really-fight-cancer/ ...
00:12:15
September 06, 2021
CRISPR gene editing: In search of perfection
CRISPR gene editing: In search of perfe...
This episode is also available as a blog post: https://mdforlives.blog/2021/08/31/crispr-gene-editing/ --- Send...
00:07:12
August 31, 2021
Recent developments in therapy for HER2+ and HER2- Non-small cell lung cancer
Recent developments in therapy for HER2...
This episode is also available as a blog post: https://mdforlives.blog/2021/08/30/therapy-for-her2ve-her2-ve-and-n...
00:08:49
August 30, 2021
Advances in our understanding of rosacea will help patients
Advances in our understanding of rosace...
This episode is also available as a blog post: https://mdforlives.blog/2021/08/23/understanding-of-rosacea-will-he...
00:06:56
August 23, 2021
Ovarian Cancer: The new normal- Standards of care before, during and after the pandemic – Part 1
Ovarian Cancer: The new normal- Standar...
This episode is also available as a blog post: https://mdforlives.blog/2021/08/19/ovarian-cancer-standards-care-du...
00:06:01
August 19, 2021
Current and future paradigms in the management of Esophageal Cancer
Current and future paradigms in the man...
This episode is also available as a blog post: https://mdforlives.blog/2021/08/17/paradigms-in-the-management-of-e...
00:07:57
August 17, 2021
SGLT2 inhibitors and GLP1 agonists in Diabetes Type 2
SGLT2 inhibitors and GLP1 agonists in D...
This episode is also available as a blog post: https://mdforlives.blog/2021/08/13/sglt2-inhibitors-glp1-agonists-i...
00:02:06
August 13, 2021
FDA Approves Pradaxa (Dabigatran Etexilate), the First Oral Anticoagulant for Children
FDA Approves Pradaxa (Dabigatran Etexil...
This episode is also available as a blog post: https://mdforlives.blog/2021/08/10/pradaxa-first-oral-anticoagulant...
00:06:38
August 10, 2021
Early-Life Antibiotic Exposure, Gut Microbiome, and Neurodevelopment
Early-Life Antibiotic Exposure, Gut Mic...
This episode is also available as a blog post: https://mdforlives.blog/2021/08/04/early-life-antibiotic-exposure-g...
00:06:48
August 04, 2021
Cytokine-blocking monoclonal antibody helps prevent asthma exacerbations
Cytokine-blocking monoclonal antibody h...
This episode is also available as a blog post: https://mdforlives.blog/2021/08/02/cytokine-blocking-monoclonal-ant...
00:06:53
August 02, 2021
The changing landscape of HER2-positive Breast Cancer
The changing landscape of HER2-positive...
This episode is also available as a blog post: https://mdforlives.blog/2021/07/28/changing-landscape-of-her2-posit...
00:06:02
July 28, 2021
Biomarker for Early Detection of Pancreatic Cancer
Biomarker for Early Detection of Pancre...
This episode is also available as a blog post: https://mdforlives.blog/2021/07/13/biomarker-for-early-detection-of...
00:07:18
July 13, 2021
Avapritinib approved by FDA for use in systemic mastocytosis
Avapritinib approved by FDA for use in ...
This episode is also available as a blog post: https://mdforlives.blog/2021/07/12/avapritinib-approved-for-systemi...
00:06:44
July 12, 2021
Dapagliflozin approved for use in chronic kidney disease
Dapagliflozin approved for use in chron...
This episode is also available as a blog post: https://mdforlives.blog/2021/07/05/dapagliflozin-approved-for-chron...
00:07:16
July 05, 2021
Link Between COVID-19 and Alzheimer’s Disease-Like Cognitive Impairment
Link Between COVID-19 and Alzheimer’s...
This episode is also available as a blog post: https://mdforlives.blog/2021/06/29/covid-19-alzheimers-cognitive-im...
00:06:07
June 30, 2021
Metastasis Prevention – A New Weapon in the Fight Against Cancer
Metastasis Prevention – A New Weapon ...
This episode is also available as a blog post: https://mdforlives.blog/2021/06/28/metastasis-prevention-in-the-fig...
00:06:24
June 28, 2021
Why do our sporting heroes suddenly collapse with heart attacks?
Why do our sporting heroes suddenly col...
This episode is also available as a blog post: https://mdforlives.blog/2021/06/23/why-sporting-heroes-suddenly-col...
00:08:22
June 23, 2021
Psilocybin in clinical trials for depression, anxiety, and other conditions
Psilocybin in clinical trials for depre...
This episode is also available as a blog post: https://mdforlives.blog/2021/06/22/psilocybin-clinical-trials-for-d...
00:06:57
June 22, 2021
Clinical flow cytometry in cancer diagnosis and immune system disorders
Clinical flow cytometry in cancer diagn...
This episode is also available as a blog post: https://mdforlives.blog/2021/06/21/flow-cytometry-in-cancer-diagnos...
00:05:56
June 21, 2021
FDA Approves First KRAS-Targeted Therapy for NSCLC
FDA Approves First KRAS-Targeted Therap...
This episode is also available as a blog post: https://mdforlives.blog/2021/06/17/kras-targeted-therapy-for-nsclc/...
00:07:21
June 17, 2021
GIVE BLOOD, GIVE LIFE: World Blood Donor Day 2020
GIVE BLOOD, GIVE LIFE: World Blood Dono...
This episode is also available as a blog post: https://mdforlives.blog/2020/06/15/give-blood-give-life-world-blood...
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June 10, 2021
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June 10, 2021
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June 10, 2021
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June 08, 2021
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June 08, 2021
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June 08, 2021
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June 08, 2021
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June 08, 2021
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June 08, 2021
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June 08, 2021
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June 08, 2021
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Asthma affects around 334 million individuals around the world. Allergic asthma (AA) is linked to allergic rhinitis (AR) because of the similarities in the upper and lower airways. AR is an allergic airway disorder frequently accompanied by AA.2 AR was found to be present in 2~25% of children and 10~40% of adults worldwide.

Understanding the characterization, microbiota, and potential role of probiotic intervention in respiratory tract allergies such as AA and AR can benefit healthcare professionals. A recent study provides an overview of probiotics concerning AA and AR and changes in gut microbiota.

How was the research carried out?

The researchers conducted a systematic literature search that included observational studies (cross-sectional, cohort, or case-control) and experimental studies to discuss the effect of probiotics on respiratory tract allergy illness and gut microbiota.

Atopic dermatitis, food allergies, intestinal problems, and respiratory microbiota were employed as exclusion criteria to eliminate probably correlated comorbidities.

Using the key phrases, the team conducted searches in PubMed, Google Scholar, and Medline. Studies from all years were considered, emphasizing those published in the last 10 years.

Treatment options for Allergic Asthma and Rhinitis

Asthma is caused by a mix of hereditary and environmental variables that are poorly understood. By using genome-wide association, researchers have mapped the effects of single nucleotide polymorphisms (SNPs) on the presence of childhood-onset asthma.

Inhaled corticosteroids, oral corticosteroids, and glucocorticoids are currently used to treat asthma. However, they are ineffective in curing the fundamental cause, and the high medical costs can be financially demanding.

Avoiding allergens, using H1-antihistamines or intranasal corticosteroids, and allergen-specific immunotherapy (AIT) are all treatment options for AR. However, drugs for allergic rhinitis (such as histamine antagonists) might have adverse side effects like weariness.

Commensal gut microbiota and early immunity

The commensal gut microbiota influences immunity. Microbes populate the body’s mucosal surfaces from infancy onward, triggering the creation of immunological homeostasis and defense systems.

What role does gut microbiota play in allergic conditions?

Early gut microbiota colonization affects immune status during childhood, and early gut microecological dysregulation due to various factors (mode of delivery, feeding practices, antibiotic use, environmental exposure, etc.) may disrupt homeostatic regulatory mechanisms between T helper 1/ T helper 2 (Th1/Th2) cells, which may negatively affect immune tolerance development and eventually trigger the allergic reaction process, increasing the risk of allergy.

The gut microbiota is essential in the maturation of the postnatal immune system, particularly in immunological tolerance. In addition, by working on intrinsic and adaptive immunity, the gut microbiota protects the host from allergic responses.

Do AA and AR alter gut microbiota?

According to several research articles, a reduced quantity of gut bacteria, such as Bifidobacterium species, has been linked to an increased risk of allergy diseases in children. In addition, other pro- and anti-inflammatory metabolites, such as biogenic amines (including histamine) and oxylipins, have recently been discovered in the human gut microbiota. The number of histamine-secreting bacteria in asthma sufferers’ feces was substantially higher than in non-asthmatic volunteers.

Recent research suggests that a higher bacterial ratio between Klebsiella (an opportunistic pathogen) and Bifidobacterium (commensal bacteria of the gut microbiota) may predispose them to allergic diseases; however, other research suggests that using probiotics in infants may favorably alter this ratio and prevent the development of allergic diseases in the future.

What can be the potential benefits of probiotics in allergic diseases?

According to clinical and laboratory evidence, probiotics have a therapeutic effect on allergic diseases by modifying gut microbiota and influencing host immunity, promoting the maintenance of standard immunological tolerance.

How do probiotics work?

In both mice and humans, probiotics can increase the expression of adhesion molecules and stimulate the innate immune system, antigen-presenting cells (APC), and natural killer (NK) cells. In addition, probiotics promote adaptive immunity, resulting in the production of immunoglobulin G (IgG) and Immunoglobulin A (IgA) antibodies in response to probiotic ingestion.

A variety of immunopathogenic diseases, including AA and AR, are mediated by insufficient probiotic bacteria alone or insufficiency combined with immune system stimulation by invasive pathogens.

What is the effect of probiotics on the regulation of AR?

In a recent animal study, researchers looked into the effects of oral administration of Bifidobacterium (B. breve) in AR. They discovered that B. breve suppresses type II helper T cell immunological responses while increasing CD4+CD25+ regulatory T (Treg) cell activity. Another animal study found that using a probiotic mixture (PM) of Bifidobacterium longum IM55 and Lactobacillus plantarum IM55 isolated from human feces and kimchi to treat AR by repairing Th2/Treg imbalance and gut microbiota problems could help to reduce AR.

Are Probiotics Effective for Respiratory Allergies and Gut Microbiota

Effect of probiotics on allergic rhinitis

In a randomized, double-blind, placebo-controlled study involving 40 children from around the world, researchers discovered significant improvements in allergic rhinitis symptoms and quality of life in children given a probiotic mixture (Bifidobacterium longum BB536, Bifidobacterium infantis M-63, and Bifidobacterium shortum M-16V), with all parameters significantly better than the placebo group.

What effects do probiotics have on the regulation of AA?

Many animal and human clinical trials have shown that probiotic supplementation during the prenatal and postnatal periods is expected to play an important role in asthma prevention. As a result, probiotic supplementation could be a novel approach to preventing and treating allergy disorders.

Are Probiotics Effective for Respiratory Allergies and Gut Microbiota

Effect of probiotics on allergic asthma

Lactobacillus paracasei L9 was given to OVA-induced acute asthma mice, and researchers discovered that it reduced airway hyperresponsiveness and the proportion of eosinophils in bronchoalveolar lavage fluid by rectifying the Th2/Th1 immunological imbalance in the mice’s lungs, thus relieving asthma.

What does the future hold for probiotics in the treatment of respiratory allergies?

Probiotics reduced allergen-induced hyperreactivity and inflammation, as well as cytokine release. While probiotics did not completely remove allergies, they did help to lower the frequency and duration of allergy symptoms. On the other hand, probiotics’ effects depend on their species or strain, their metabolites, and the patient’s gut microbiota.

Even though multiple studies have been undertaken, more fundamental and human investigations are needed to confirm the role of probiotics in allergy treatment. Most recent research in the clinic has discovered preliminary effects of probiotics in treating allergic disorders. Patients should be included in future trials, and probiotic delivery should be standardized, so that sound data and precise information about the therapeutic benefits of probiotics can be provided to healthcare professionals. Nevertheless, probiotics’ use in treating respiratory allergic disorders appears to be promising.

References:

  1. https://pubmed.ncbi.nlm.nih.gov/31734564/
  2. https://pubmed.ncbi.nlm.nih.gov/30347544/
  3. https://pubmed.ncbi.nlm.nih.gov/32075727/
  4. https://www.frontiersin.org/articles/10.3389/fnut.2022.821900/full
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